Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus
Antioxidant status imbalance and inflammatory process are cooperative events involved in type 2 diabetes mellitus. This study aimed to investigate superoxide dismutase as a potential biomarkers of antioxidant imbalance, matrix-metaloprotinase-9, and interleukin -18 as biomarkers of inflammation in serum and to estimate the effects of other confounding factors gender, age and finally measuring the relation among the interested biomarkers.
This case - control study included 50 patients, and 45 of healthy subjects matched age –gender were also enrolled in this study as a control group. The focused parameters were measured using ELISA technique. There was significant reduction in the serum superoxide dismutase level and significant elevation in serum matrix- metaloptotinase-9 and interleukin -18 levels which have been associated with diabetes.
This finding may explain the role of the defect in antioxidants status leading to significant reduction in serum superoxide dismutase levels associated with increased inflammatory process leading to significant elevations of a matrix- metaloptotinase-9 and interleukin -18. These parameters added a diagnostic information and evaluated as potential tools for disease risk prediction.
Keywords: Type 2 diabetes mellitus, Superoxide dismutase, Matrix metaloptotinase-9 and Interleukin -18.